The world has missed its 1.5ºC target. The fight now turns to how far temperatures rise beyond it — and what can still be done to bring them back down.

The world has failed to meet the Paris Agreement target of limiting global warming to 1.5ºC, the United Nations Environment Programme (UNEP) declared on Wednesday.

In a sprawling 141-page report, UNEP found there is no realistic pathway to prevent warming from exceeding the threshold. “The most stringent emission reduction pathways that were available around the time of the Paris Agreement are no longer feasible,” it states.

The finding is the first by a UN agency to treat the 1.5ºC target as no longer within reach – and the math doesn’t give its authors much choice. To stay under 1.5ºC, total emissions from 2026 onward cannot exceed 130 billion tonnes of CO2. With current emissions at roughly 40 billion tonnes per year and still rising, that restriction will be breached in just three years.

“Despite decades of scientific warnings, despite the growing scientific evidence, the resulting climate commitments have not produced sufficiently rapid emission reductions,” said Debra Roberts, a lead author and former co-chair of the Intergovernmental Panel on Climate Change (IPCC) Working Group II. “Exceeding 1.5ºC is now unavoidable.”

The report identifies just one pathway that would keep the world within its remaining carbon budget: global CO₂ emissions would have to fall steadily from 2025 to zero by 2031. Under current policies, the world is headed for 2.6C by century’s end.

“All of our pathways forward are overshoot pathways,” Roberts added. “We are clearly entering uncharted territory.”

With limiting the peak and length of the overshoot the last remaining option, UNEP is blunt: “This is by no means an acceptable or preferred pathway. It is simply the best remaining option.”

‘No good options’ above 1.5ºC

UNEP Executive Director Inger Andersen addresses reporters ahead of the report’s launch.

While scientific projections have long assessed that remaining beneath this threshold would be impossible on current emissions trajectories, the change in language by UNEP is an historic break in climate diplomacy from the hope of Paris to the ongoing deadlock over the phase-out of fossil fuels set to continue in November at COP31.

UNEP Executive Director Inger Andersen, launching the findings at the end of a summer that saw Arctic temperatures soar to 32ºC, wildfires scorch Europe and the Americas, and sea-level rise threaten hundreds of millions of coastal residents, said the evidence demands immediate action.

“Across the globe, extreme heat waves are already proving that climate change impacts will strike faster, hit harder, and last longer, costing more lives and causing deeper disruption,” Andersen said. “Obviously, we have climate procrastinated.” 

Crossing the 1.5ºC mark would bring an “intensification of extreme weather,” loss of small island states, and growing risks to human health, food and water security. “There are no good outcomes if we remain above 1.5ºC,” she said.

With human-induced warming already nearing 1.4C and rising at around a quarter degree per decade, the World Meteorological Organization forecasts a three-in-four chance the 2026–2030 five-year mean will breach the Paris target.

At current levels, roughly every five years of delay adds at least a tenth of a degree of global warming to the maximum level we will experience.

“The future will bring many unknowns, but we do know that decisions taken now and in the next few years will determine if we have a chance of returning to 1.5ºC or below,” Andersen said.

The report is the first in a series of major assessments in the run-up to the UN climate summit, COP31, in Antalya, Turkey, in November, where governments will again confront a deadlock over how quickly to phase out fossil fuels. 

For some observers, the report’s relative silence on the fuels driving the crisis – mentioned in passing just once in nearly 150 pages – is all the more striking as COP31 approaches.

“Although UNEP does a good job of describing the hole we’ve dug ourselves into, it does a poor job of showing us that there is a way out,” said Bill Hare, CEO of Climate Analytics, noting that the report only makes only a single passive reference to phasing out fossil fuels.

“Ultimately the report’s neglect of some fundamentally important mitigation analysis risks turning it into a call to apathy rather than a call to arms,” Hare said.

Fire, water, ice

The planet’s frozen water is rapidly disappearing, threatening sea levels, freshwater supplies and climate stability.

The report lands as the latest warning of the upheaval climate change is causing globally, and how much worse it might get.

New threats to human health are already emerging. Rising temperatures are shifting vector-borne diseases to higher latitudes, increasing pathogen spillover risk, the report found. Food production could fall by 14% by 2050 under a high-emissions scenario, putting tens to hundreds of millions, concentrated in sub-Saharan Africa, South Asia and Central America, at risk of malnutrition. 

Heat-related deaths during a 2025 European heatwave tripled, an increase attributed to global warming. Deadly heat seasons once expected every 100 years now arrive every 10 to 20 years. More than five billion people are projected to experience at least a month of extreme heat every year by 2050.

Critical environmental systems that regulate the climate – storing carbon in forests, soils and frozen ground, or reflecting sunlight back into space – are also at risk of irreversible damage.

Parts of the Western Antarctic Ice Sheet may already have crossed thresholds for irreversible ice loss. More than 40% of total global glacier loss since the 1970s has occurred in just the last decade, with global peak glacier extinction possible as early as 2041. 

More than 80% of tropical coral reefs bleached between 2023 and 2025, with warm-water corals now facing heat stress on a near-annual basis and “a low possibility” of surviving this century under any scenario. Essential carbon sinks like rainforests are facing die-off scenarios, with nearly 40% of the Amazon’s surface area at risk of disappearing by 2100.

As damage mounts, returning to 1.5ºC – a major effort calculated in decades in a best-case scenario – does not constitute a rewind, the report stresses. Even if temperatures eventually fall, sea levels will continue rising, species driven to extinction will not return, and carbon released from thawing permafrost cannot simply be recovered. Ecosystems that collapse during overshoot cannot easily reassemble as temperatures fall. 

“The loss of biodiversity will weaken natural systems on which our lives and livelihoods depend, and will impact our ability to withdraw carbon from the atmosphere,” said Roberts. “Returning to 1.5ºC doesn’t mean we return to the same world we left,” Roberts added. 

‘Collapse of habitability’ on low-lying islands 

Small developing island states are highly vulnerable to the effects of climate change and rely on universal diplomatic processes to ensure they hold equal weight to major global powers.
Small developing island states are very vulnerable to the effects of climate change and rely on universal diplomatic processes to ensure they hold equal weight to major global powers.

For small island developing states, the stakes are ones of life and death. The five to 10 centimetres of sea-level rise expected by 2050 is projected to double flooding across the Indian Ocean and tropical Pacific, supercharging storm surges, turning freshwater salty, and pushing floods deeper inland than at any point in history.

For these nations, “the collapse of habitability has already begun,” the report warns. 

“This report is a fork-in-the-road moment for the planet. It is hard to overstate the depth of emotion for those of us living on the frontline after having fought so hard to put the 1.5 degree limit at the heart of the Paris Agreement,” said Palau President Surangel Whipps Jr. “It is a further glimpse into a perilous future that has already arrived.” 

“We need to see an urgent and unprecedented increase in political will and investment in a climate-safe future,” Whipps added. “Nobody can read this report and conclude otherwise.”

For these low-lying nations, the threat is already here. But the consequences of remaining above 1.5ºC for an extended period will ultimately reach far beyond their shores. 

UNEP warns prolonged warming raises the risk of triggering irreversible tipping points in global systems, including the West Antarctic and Greenland ice sheets, the Amazon rainforest and the Atlantic Meridional Overturning Circulation, or AMOC, a vital system of ocean currents that helps regulate temperatures across the Atlantic and Europe. 

Such changes could, the report warns, “reshape the world forever.”

“Exceedance of 1.5°C should not be interpreted as safe or acceptable,” it states. Even if a return to below 1.5°C is secured — an outcome the report describes as “deeply uncertain” — “many nations and communities will face irreversible losses and permanently changed conditions.”

The 1.8ºC ceiling

Under UNEP’s most optimistic scenario – full implementation of all national climate plans plus all net-zero pledges – peak warming still reaches approximately 1.8C. Getting there requires roughly halving global emissions by 2035.

“We’re really looking at 1.8ºC as being the kind of maximum, because the feasibility of the responses then becomes really, really questionable,” Roberts said. “You get a cascading effect from all the irreversible changes.”

Wildfires weaken forest carbon stocks, drought reduces hydropower, heat degrades solar panel efficiency, and rising temperatures drive methane emissions from wetlands, eroding the systems the world would depend on to reverse warming.

A decade of warming at the current rate, the report finds, could take 50 years to reverse even under optimistic assumptions. The lead for reducing emissions should fall on countries with “greater historical responsibility for climate change and capability to address it should act the hardest and fastest,” the report states.

That tension – and the point advanced in the report that many advanced economies will need to go beyond net-zero to achieve net-negative emissions – is likely to resurface at COP31 in Antalya, Turkey, later this year, as oil-producing and high-income states fight calls to phase out fossil fuels. 

“This summer’s scorching heat, raging wildfires and deadly floods are a warning of what lies ahead,” UN Secretary-General António Guterres said. “We must make the overshoot above 1.5 degrees as small and short as possible. That demands an overshoot of ambition.”

Image Credits: Chris LeBoutiller, USGS, Unsplash/Ernests Vaga.

Women survivors of brutal violence in South Sudan share their stories with UN Deputy Secretary-General Amina Mohammed in 2018. Human rights groups warn that religion, culture and tradition are being ‘weaponised’ to undermine women’s rights.

A draft charter on “family, sovereignty and values”, which would significantly undermine the rights of African women and girls, is not likely to be presented to the African Union (AU) General Assembly next February – despite a push from its conservative sponsors.

“That draft instrument has not got to the AU yet, and it is important to state categorically that it was not proposed by the African Union,” said ⁠Dr Robert Eno, Registrar of the AU’s African Court on Human and Peoples’ Rights.

“I’ve checked with my colleagues [at the AU headquarters] in Addis Ababa, and they have not received it. It is not scheduled,” Eno told a recent webinar organised by Sexual Health with Equity & Rights (SHE & Rights) on countering anti-rights efforts.

“I can assure you that, if it goes to the AU, it will not go straight to the Assembly. There is a process, and it’s a very long process,” said Eno.

The draft charter will undermine one of the few continental treaties that protects women’s rights and promotes gender equality, known as the Maputo Protocol

The Maputo Protocol, which has been ratified by 46 of the continent’s 54 countries, commits to eliminating “all forms of discrimination against women”, including “harmful cultural and traditional practices”such as female genital mutilation and child marriage.

It also allows for abortion “in cases of sexual assault, rape, incest, and where the continued pregnancy endangers the mental and physical health of the mother or the life of the mother or the foetus”.

Gender equality ‘strengthens families’

The draft was developed over four annual gatherings of conservatives, three hosted by the Ugandan government and the fourth hosted by Ghana’s parliament in June.

These events have been supported by international right-wing governments and organisations, including the far-right United States group, Family Watch International (FWI) and the Russian government.

Members of Parliament from approximately 20 countries attended the conference in Ghana where the draft was presented, but that meeting has no legal status. 

Eno urged human rights organisations to “resist the temptation to answer anti-rights narratives simply with more legal language, more technical terminology, or stronger denunciations”.

Instead, said Eno, “our response must offer an alternative, and importantly, a better alternative, and to persuade people that advancing the rights to health and gender equality does not threaten the family, society, culture, or religion. 

“On the contrary, it strengthens families, protects communities, and promotes the well-being and dignity of all members of society.”

⁠Dr Robert Eno, Registrar of the AU’s African Court on Human and Peoples’ Rights, addressing the webinar.

‘Weaponising religion, culture, and tradition’

Samah Hadid, the global executive director of Musawah, told the webinar that the anti-rights movement is “weaponising and misusing religion, culture, and tradition to justify gender discrimination and injustice” and “evade compliance with human rights treaties and frameworks”. 

Her organisation promotes equality and justice in the Muslim family and advances human rights for women living in Muslim contexts.

But, said Hadid, attacks on women’s rights and their health rights are intensifying because “the anti-rights movement and these forces behind them are more coordinated; they’re more resourced”.

⁠Rehema Namukose, Musawah’s senior regional programme officer for sub-Saharan Africa, said that, across Africa, “family values are used to justify harmful practices”. 

In Somalia, for example, girls who have been raped are often forced to marry their rapists to save their family’s “honour”. Several countries also justify the economic and social subordination of women. 

Namukose said many grassroots groups are “so discouraged” by how anti-rights groups have used legislation to curb rights.

Laws that push for “homophobic family protection legislation move at a high speed, while laws that advance gender equality are being stalled,” Namukose said, with Uganda, Ghana and Senegal all passing anti-LGBTQ laws at record speed in the past year.

Human rights defenders protest against Uganda’s anti-LGBTQ law.

‘Family protection to justify exclusion’

Fatou Bintou Sallah from the Initiative for Strategic Litigation in Africa (ISLA) said that the draft charter uses family protection to justify exclusion; sovereignty to resist accountability; and culture and values to limit equality protections. 

Sallah, a former magistrate in Gambia, said that “the legal question is what the charter makes ideas [of family, sovereignty and values] do to existing rights and obligations”. 

For example, the charter’s narrow definition of “family” as a marriage between a man and a woman and their children, “matters because family recognition affects inheritance,  housing, custody, migration status, social protection, and legal recognition before the state”.

Sallah added: “If national law defines family narrowly, then protections linked to family can also become narrow. That can affect women-headed households, extended family networks, unmarried women, children, LGBTQ persons, and others who do not fit the preferred model by the state.”

Fate of rural girls

⁠Vimbai Kapurura, the executive director of Girls Not Brides in Eswatini, said that while her country has made progress in reducing teenage motherhood, the rate is still high in rural and poor households.

“The unmet contraceptive need in sexually active girls between the ages of 15 and 19 is 46%,” said Kapurura.

Eswatini faces its Universal Periodic Review (UPR) this November. This United Nations Human Rights Council (UNHRC) peer-review mechanism assesses the human rights performance of all 193 UN Member States every 4.5 years. Governments and civil society submit reports to the UNHRC, and the review takes place at a meeting between the member state and the UNHRC working group in Geneva.

Kapurura said the UPR offered the opportunity to “pause and ask what has changed, who is experiencing that change, who is still being left behind, and are the rural girls experiencing the same progress?”

Kapurura added that her organisation engages men “as allies and partners”.

“If we are really serious about gender equality, sustainability can’t come from women and girls alone. Men are part of families. They are part of communities. They are part of the institutions and systems,” she stressed.

“They have a critical role to play, not just in speaking over women and girls, and not in taking over feminist spaces, but in standing alongside women and girls and helping transform the attitudes, the behaviours, and systems that sustain inequality.”

Image Credits: Isaac Billy/ UN Photo, Peter Tatchwell Foundation.

Namibian officials spoke on behalf of the African region at the World Health Organization (WHO) negotiations on pathogen-sharing in March. The terms of the US bilateral agreement undermine these talks.

Namibia has rejected the United States’ demands for sharing health data and pathogen information during negotiations for renewed US support for its HIV programme, according to The Namibian newspaper.

In the past few years, the country has received around $45 million a year in support from the US President’s Emergency Plan for AIDS Relief (PEPFAR), and a total of over $1 billion since 2003.

However, the Trump administration is replacing PEPFAR and other health grants with new bilateral agreements in terms of its America First Global Health Strategy. These focus on countries’ ability to contain disease outbreaks as well as support for HIV and other key health programmes.

US demands for data and sharing of pathogen information have run into headwinds in other African countries.

Zimbabwe and Ghana have also rejected the US data- and pathogen-sharing demands, while the memorandums of understanding (MOUs) that the US has reached with Kenya and the Democratic Republic of Congo (DRC) both face legal challenges from civil society groups.

Undermining PABS?

World Health Organization (WHO) member states are currently in sensitive talks about how to share information about dangerous pathogens, and any medical products that arise from this sharing. 

The pathogen access and benefit-sharing (PABS) system is the last outstanding piece of the Pandemic Agreement, and Namibia has played a central role in representing the African region at the talks.

However, the US withdrew from the WHO when Donald Trump assumed the presidency in January 2025, and its bilateral health agreements, which demand access to pathogen information without guaranteeing that any benefits will be shared, are a direct challenge to a WHO PABS system.

The Namibian government is concerned that the data- and pathogen-sharing demands do not comply with its laws, infringing both constitutional privacy rights and national sovereignty over biological resources, according to the newspaper.

The government is concerned that the US demands contravene its Access to Biological and Generic Resources and Associated Knowledge Act and its Public and Environmental Health Act.

The talks are ongoing, but the loss of $45 million will affect the employment of health workers and the delivery of services. The Namibian

Flood flattened nearly everything in its way, leaving only a few homes still standing in Betrawati, Rasuwa. Many of these homes are filled with debris and in some cases, with dead bodies of those trapped inside.

KATHMANDU – Shekhar Lamichhane is grieving even as he struggles to breathe. The 65-year-old asthma patient needs oxygen support. Some of his family members, including siblings, were swept away in Nepal’s flash flood on 26 August when glacial ice and rock slammed into the valley below near the Nepal–China border.

“I am on oxygen support. I have severe asthma and the electricity has been gone since the flood. I am struggling to breathe without support,” Lamichhane said.

The flash flood carrying rocks and debris gushed through the Nepal–Tibet border into northern Nepal. By Tuesday (1 September), over 1003 people were reported dead, and nearly 4,000 were missing.

“The sudden glacial collapse and flash flood is a devastating reminder of how fragile these mountain environments can be, particularly in the Hindu Kush Himalayas. For years, scientists and local communities have been warning that the Hindu Kush Himalayas are at huge risk from climate change,” said Simon Stiell, executive secretary of UN Climate Change, in the aftermath of the floods.

Nepal – a classic example of what developing nations face

Nepal is the classic example of what climate scientists have been warning of: small nations facing disproportionate climate impacts despite contributing the least to climate change.

In 2024, Nepal emitted around 0.05% of the world’s CO2 emissions, according to Our World in Data, based at Oxford University.

Nestled in the pristine and fragile Himalayas, Nepal gets nearly all of its electricity from hydropower, and a fraction from solar and wind.

Black carbon, the fine particles that remain after incomplete combustion of fuels, is a regional problem, though. Black carbon concentrations have increased by approximately 7.74% since 2000, according to a report by Climate Trends. This has contributed to faster warming of the Himalayan glaciers.

A trail of destruction

Shekhar Lamichhane charging his electric plug-in oxygen support device on the terrace of a house in Kalikasthan, Rasuwa. After days of without oxygen support Lamichhane was able to use his oxygen support to ease his Asthma.

Preliminary estimates by scientists suggest that the enormous mass of bedrock and glacier ice broke off a slope north of Langtang Lirung and slammed into the valley about 4,000 feet (1,200 meters) below – a distance roughly three times the height of the Eiffel Tower.

The debris fell into the Lhende River, which flows from Tibet into Nepal, sending floodwater and debris surging downstream.

“This was an unprecedented and unexpected disaster. There was simply no detection and no time to issue a warning. The event was a sudden-onset hazard that could not be captured by conventional warning systems,” said Dr Farooq Azam, Senior Cryosphere Specialist and Intervention Manager at Nepal-based ICIMOD, a Nepal-based regional research organisation.

A rapid assessment of the disaster by a group of International scientists, published by HiRisk, agrees that, given the “rapid speed of the initial avalanche, warning time from conventional in-channel systems would have been minimal and likely insufficient for successful evacuation at the Nepal-China border checkpoint at Rasuwagadhi”.

However, they assert that further downstream, “with warning times of 10 minutes or more, comprehensive and well-capacitated systems could have saved a significant number of lives”.

The HiRisk report notes that, while early warning systems (EWS) focused on several glacial lakes in China were recently set up, no operational EWS were set up “for glacier-related hazards”.

They also point to “some pre-event indications that the ice surface sped up just prior to the event”, including that “meltwater had turned visibly brown by 24 August” and “some indication of a crack propagating into the surrounding bedrock slope in the days before the event”.

Seismic event

Satellite imagery shows the devastation in Syapru Besi, a mountain village in Rasuwa District, Nepal. Left: Post-event image taken on 27the of August and on the right is the pre-event image.

The ice and rock collapse from the glacier was so powerful that it caused seismic activity equivalent to a 5.2‑magnitude earthquake, according to the US Geological Survey at 8.37 am local time. Sediment and boulders moved rapidly through the Bhote Koshi and Trishuli river systems, flattening everything in its path.

According to the HiRisk report, satellite-based preliminary flood assessments show that “at least 68 bridges were hit, including 33 suspension bridges and 35 motorable bridges and 40 km of highway were washed away”.

“Open-access datasets indicate that 12,944 buildings are located within the floodplain, with structural heights up to 9 meters.”

Nepal struggles to coordinate relief efforts

Mud covers Nuwakot district in central-northern Nepal following devastating flash floods.

Nepal’s government is facing criticism for not accepting international assistance quickly enough – a delay some say hindered early rescue operations.

Government spokesperson Sasmit Pokharel rejected the claim. “We are in contact and discussion with countries through the Ministry of Foreign Affairs, and we are constantly assessing the situation in the affected area,” Pokharel said during a press briefing on Monday.

He added that rescue teams from India, China, South Korea, and other countries are already on the ground supporting search-and-rescue operations.

“To avoid possible epidemics, a special medical team has been deployed with necessary medicines,” he said. “Children, women, and people with pre-existing health issues are prioritized.”

He also addressed public criticism over the handling of dead bodies. Due to limited space and technology, some unaccounted or unidentified bodies have been buried in Chitwan,  which has drawn concern from families and community members.

“We are only managing the body as per the law and science; the body is not destroyed,” Pokhrel said. “In the future, if relatives come forward to claim it, all doors are open, and either the body or its remains will be handed over through DNA matching.”

Before burial, DNA samples, fingerprints, and other necessary details are documented and securely stored, he added.

“But the solutions to global heating are equally clear, especially a faster global shift from fossil fuels to renewables and more investment in climate resilience,” he added.

Nepal disaster – a reminder for regional collaboration

Nepal’s share to global carbon emissions in 2024 when compared to China, United States, Europe and its neighbours India and China. Nepal emitted 0.05% of the world’s CO2 emissions in 2024.

The Hindu Kush Himalayan system spans multiple countries, many of them with ongoing border disputes, such as Pakistan-India and China-India. The flooding in Nepal highlights the need for regional collaboration that is currently missing.

Over the past five decades, the glaciers here have recorded negative mass for 89% of the observed years, according to data from ICIMOD, a Nepal-based regional research organisation.

Melting glaciers do not just have devastating consequences for mountain communities, but also for the downstream countries.

Early warning systems can save lives but have limits

WMO marked 75th year of its existence by making a push for countries to ramp up early warning systems as climate impacts intensify.

Stories are emerging of communities downstream where even the 15-minute warning from those hit hard upstream saved hundreds of lives. But scientists are sceptical.

“Early warning systems are being sold as the fix, but no siren can outrun a mountainside collapsing in seconds. The real failure sits upstream, in land-use decisions that pushed settlements and infrastructure onto riverbanks our ancestors deliberately avoided, and in a global economy still burning the fossil fuels that are cooking these glaciers from the inside out,” said Professor Anjal Prakash of FLAME University in India and an IPCC author.

“Every villager who watched that valley disappear paid for emissions decisions made thousands of kilometres away,” he added.

The UN’s Stiell also echoed a similar sentiment. “The solutions to global heating are equally clear, especially a faster global shift from fossil fuels to renewables and more investment in climate resilience.”

Back in Nepal, Lamichhane shelters on the terrace of a house just above Betrawati, one of the flooded towns. He has managed to charge his electric oxygen concentrator device with the help of relief workers who brought generator‑powered charging devices as the power is out.

Remembering how it felt when the floodwaters came, he said, “It was making a sound like a helicopter makes. It was like all clouds and dust running high in the sky. The river climbed up the mountains on both sides and took everything in its way.”

Image Credits: Manish Aryal, Copernicus Emergency Management Service (CEMS) situation report, UNICEF/Laxmi Prasad Ngakhusi, Our World in Data, WMO.

Violence, economic distress and funding cuts leave nearly a million people in the West Bank facing severe food insecurity, according to the WFP.
Violence, economic distress and funding cuts leave nearly a million people in the West Bank facing severe food insecurity, according to the World Food Programme.

Around 200,000 people in the Israeli-occupied West Bank will lose access to vital food aid from the United Nations World Food Programme (WFP) due to funding cuts, exacerbating food insecurity. In the Gaza Strip, the nutrition and health crisis is set to worsen further due to a lack of medical supplies and sanitation, the World Health Organization (WHO) warns.

Over the past two years, the number of people affected by food insecurity in the West Bank has doubled to almost one million – over a quarter of the population, according to latest WFP data. Due to drastic funding shortfalls, the WFP is halving its aid to the 400,000 recipients starting in September, the organisation announced.

Already, 12% of the surveyed population suffer from inadequate food consumption, whilst a third of West Bank households can no longer afford a nutritious diet.

“Food may be available in the markets, but people simply cannot afford it,” said WFP Country Director Shaun Hughes, describing the crisis at a UN press briefing in Geneva on Tuesday.

In future, only the most needy families will receive cash support of around 50 shekels (under $20) per person per month. The cuts impact the provision of vouchers, food, livelihood support and nutritional aid for children and pregnant women.

Economic crisis and rising settler violence

WFP’s Shaun Hughes warns funding cuts deepen severe food insecurity.
WFP’s Shaun Hughes warns funding cuts deepen severe food insecurity.

The West Bank’s economy is in a deep economic crisis on two fronts simultaneously. Unemployment now stands at 30% after Israel closed its gates to most Palestinian workers following the 7 October 2023 Hamas-led massacre in Israel.

At the same time, the governing Palestinian Authority (PA) has been economically crippled by the refusal of Israel’s hardline government to transfer some $5 billion, to date, in import and customs taxes on goods entering the West Bank as it is legally obliged to do. Normally, such transfers make up about 70% of the PA’s budget, and the withheld funds are mostly earmarked for salaries, particularly for employees in healthcare and education. The PA, meanwhile, has also been plagued by widespread corruption, according to Freedom House, and immense public debt, estimated by the World Bank at $4.8 billion by the end of 2025.

According to WFP data, 76% of all West Bank households have thus experienced a significant decline in their income. Against that context, the WFP aid payments represent crucial safety nets for many recipients facing severe financial crisis in the conflict-ridden region.

However, Hughes also blames rising settler violence, Israeli military operations, roadblocks, and arbitrary house demolitions for exacerbating the situation.

“In my recent visits to the West Bank, I have witnessed families once thriving and earning a living off their land now forced from their homes, their livelihoods destroyed. They now find themselves in a chokehold,” he said.

Israeli Prime Minister Benjamin Netanyahu recently criticised violent acts in the West Bank as criminal and damaging to Israel’s standing in the world. But critics, including voices in the military, say that his government has failed entirely to show real muscle in reining in the increasingly violent and frequent settler rampages, leading to progressively greater limitations on Palestinian movement and access to their lands.

Health risks and acute food insecurity in the Gaza Strip

Stagnant water in Gaza’s makeshift camps fosters pest infestations, sharply increasing the risk of diarrhoeal diseases as food insecurity worsens.

In the Gaza Strip, too, the WFP cut cash assistance for 375,000 people by 40% back in July. To continue providing vital supplies in both areas, the organisation urgently needs an additional $386 million for the next six months, it said.

This massive funding shortfall threatens an already fragile situation on the ground. Although food deliveries have improved supplies since the October 2025 ceasefire, two-thirds of the population in the Gaza Strip continue to suffer from crisis and emergency levels of acute food insecurity. The UN-linked Integrated Food Security Classification (IPC) forecasts that high levels of acute food insecurity will affect up to 90% of the population by the end of the year if humanitarian aid is not sustained.

Indeed, chronic undernutrition has emerged as the primary challenge, according to a June survey of Gaza by UNICEF. While emergency aid stabilized acute malnutrition (wasting) at 1.3%, chronic malnutrition (stunting) now affects 12.2% of children under five. Dietary quality is also dismal: only 30.3% of children aged 6–23 months achieve minimum dietary diversity, and just 22.4% receive a minimum acceptable diet, leaving them highly vulnerable to developmental and cognitive impairments.

The nutrition crisis is compounded by catastrophic living conditions; some 94% of Gaza’s 2.1 million residents lack adequate shelter, and approximately 100,000 children and pregnant or lactating women remain in need of continuous nutritional aid.

Disease outbreaks loom amidst the destroyed infrastructure

WHO epidemiologist Reinhilde Van De Weerdt warns that contaminated water and severe medical shortages pose imminent disease threats to displaced populations in Gaza.
WHO epidemiologist Reinhilde Van De Weerdt warns that contaminated water and severe medical shortages pose imminent disease threats to displaced populations in Gaza.

After the searing heat of summer, winter rains will mean flooding in overcrowded tent cities, and that, “will spread the sewage, the waste and contaminated water into the places where people sleep, cook and care for their loved ones,” warned WHO epidemiologist Reinhilde Van De Weerdt at the UN briefing. Damp tents and mould also dramatically increase the risk of respiratory diseases, particularly among young children, she pointed out.

According to WHO data, microbiological contamination of tested water samples nearly tripled this year, rising from under 6% in January to almost 20% in August. As a result, cases of acute watery diarrhoea almost doubled from around 30,000 in March to over 58,000 recorded cases in August.

However, the WHO warns that the severely limited local laboratory capacity can currently only detect basic microbiological contaminants, meaning that further contamination remains undetected. Furthermore, stagnant water encourages the uncontrolled breeding of disease-carrying mosquitoes and pests.

Additionally, restrictive import licences have been blocking vital deliveries of medical supplies such as prosthetics and other medical aids since May 2024, according to the WHO. As a result, only 12% of those who lost limbs since the war began have been fitted with a prosthetic device, while more than 6,600 amputees in total require long-term care, said Van De Weerdt.

The WHO is calling for the accelerated import of medical supplies, including diagnostic laboratory materials for the rapid identification of viruses and bacteria. Without this equipment, the early detection and containment of potential disease outbreaks on the ground would be virtually impossible.

Israeli government pushes back against allegations

Responding to a query by Health Policy Watch, the Coordinator of Government Activities in the Territories (COGAT) stated that Israel exercises “heightened caution” regarding dual-use items due to the risk of exploitation by Hamas for military purposes, but stressed that these items are “not subject to a blanket prohibition.” The agency added that it coordinates a continuous response with UN agencies to facilitate alternative items, such as spare parts and engine oil, while fuel is brought into the Gaza Strip daily by UN agencies.

COGAT also strongly disputed claims of restrictive barriers on medical supplies, stating that “all medicines submitted for entry into the Gaza Strip are approved and cleared without restriction.” The agency maintained that advanced medical equipment – including X-ray machines, diagnostic devices, laboratory tools, and backup generators – was recently transferred to support international health facilities, including field hospitals operated by the Red Cross, the United Arab Emirates (UAE), the International Medical Corps (IMC), and UK-Med.

Responding to concerns over water infrastructure, COGAT stated that Israel actively facilitates the entry of equipment and piping to repair and maintain water networks. According to the agency, a desalination facility in southern Gaza was recently repaired and connected to the “Kela” electricity line to increase water supply. It added that 10 major water, sanitation, and hygiene (WASH) projects were recently approved, allowing international organisations to import sewage pipes, fittings, engine oil, water storage equipment, and water quality testing kits.

The Israeli Ministry of Foreign Affairs (MFA) did not respond to a query by Health Policy Watch.

See related story:

Most Gaza Palestinians Living in Dangerous, Unsanitary and Unhealthy Shelters

Image Credits: WFP/Claire Nevill, Felix Sassmannshausen/HPW, WHO.

Kenya’s President William Ruto applauds Kenyan Cabinet Secretary Musalia Mudavadi and US Secretary of State Marco Rubio after they signed an MOU for health funding.

The United States plans to cut its health funding to 18 countries by 59% of pre-2025 levels by 2030, according to a Public Citizen and Partners In Health analysis of the bilateral agreements the US has signed with these countries.

The bilateral Memorandums of Understanding (MOUs) were signed as part of the ‘America First Global Health Strategy’ adopted by the Trump administration in 2025, and are intended to rapidly wean countries off US aid by 2030.

The reduction amounts to a cut of some $2 billion to US aid dispensed before 2025, according to Public Citizen, which analysed the MOUs – some of which it initially obtained via a Freedom of Information Act (FOIA) lawsuit against the Trump administration.

Countries facing the steepest cuts are Rwanda (97% reduction), Liberia (84%), Burundi (78%), Madagascar (77%), and Sierra Leone (71%).

All MOUs require countries to make substantial co-financing commitments. These are for activities identified as priorities by the US, and do not necessarily align with the countries’ priorities. For example, the US wants all countries to improve their ability to identify disease outbreaks, so it requires substantial investment in epidemiologists and data capturers. But many recipient countries may prefer to prioritise employing health workers.

In 11 out of the 18 countries, the co-financing commitments fail to cover the US cuts over five years compared to pre-2025 government funding. 

“Countries may also struggle to meet these funding expectations,” says the analysis. “For example, Malawi would have to mobilize new funding equal to 56% of the country’s total health expenditure to meet its annualized co-financing commitment.”

Co-financing ‘punishment’

The US government also reserves the right to reduce or cease funding if countries don’t meet their co-financing commitments. In addition, the MOUs stipulate that the co-investments “may not include funding from other donors or multilateral organizations, but must be funds ‘raised directly’ by the country”, says Public Citizen and Partners In Health.

“There is no transparent logic guiding the application of penalties across countries,” their analysis notes.

If Ethiopia, Kenya, Mozambique, Cameroon, and Malawi fail to meet co-financing commitments, the US will reduce its funding by $1 for every $1 shortfall.

Uganda and Côte d’Ivoire face a 2:1 reduction. However, no penalties are specified in the MOUs with Rwanda, Liberia, Lesotho, Eswatini, Sierra Leone, Madagascar, Burundi, Botswana, and South Sudan.

Many of the MOUs also include “performance incentives” for meeting process and outbreak response metrics, but quantifying them is vague.

Seven African countries will have fewer health workers by 2030, thanks to reduced US and partner government commitments. These are Burundi, Cameroon, Eswatini, Kenya, Lesotho, Madagascar and Malawi.

“This is a major concern since the African region currently has only 46% of the health workers it needs, and by 2030 it is projected to face a health workforce shortage of 5.85 million workers,” the analysis notes.

Burundi will lose all US-funded community health workers (CHW). Malawi will lose 3,436 CHWs (72% of its total), and Madagascar, 8,200 (39%). 

Cameroon faces a 20% reduction in CHW and nurses despite already facing “a severe shortage” of both.

The one piece of good news is that the MOUs reduce the duration of controversial data-sharing and pathogen specimen-sharing agreements, which were initially for up to 25 years – despite the MOUs only lasting up to five years.

But “these agreements stand apart from the MOU itself, and most are not available in wider circulation, making a full assessment of final terms impossible in most cases”. 

Some countries have baulked at the data-sharing requirements, with Zimbabwe deciding not to pursue an MOU with the US.

Several countries point out that these data-sharing agreements, usually appendices to the MOUs, directly undermine the pathogen access and benefit-sharing (PABS) system currently being negotiated at the World Health Organization (WHO).

“These documents suggest that the Trump administration is on course to underspend on global health by billions of dollars compared to what Congress has ordered, risking lives and allowing diseases to spread,” said Peter Maybarduk, Access to Medicines director for Public Citizen.

“The administration must answer how and when it intends to invest the missing billions for health.”

Afghan women have been almost erased from public life.

Two sets of dogmas contend in Afghanistan: those of the Taliban and the West. Neither side pays the real price for their beliefs. Ordinary Afghans do with their lives. Some aid agencies labour quietly to bring help and hope through a dozen practical ways that bypass competing doctrines. They deserve support.

In March last year, 23-year-old Khatera (pseudonym) went into prolonged labour. Her village clinic in western Afghanistan was long shuttered, and the nearest help was Herat city across a swollen river. Her husband carried her across the raging waters, both submerged to the shoulders. It took them 12 hours to reach the hospital. 

Khatera’s vital signs – and those of her baby – stopped registering hours after reaching the hospital. Why were they not saved? Perhaps no medical equipment or supplies? Perhaps few trained staff? Or perhaps sheer exhaustion?

This everyday tragedy is commonplace for Afghans. Their misfortune is to be squeezed between the beliefs of their Taliban rulers and those of the international community that fled the country. This clash of convictions is fought over the easiest of targets: the defenceless bodies of millions like Khatera.

The outcome is a generation of losers, not just Afghans but those who would save them. As with all lose-lose “games”, the focus quickly shifts to ascribing blame, as in the acres of commentary around the fifth anniversary of the Taliban’s re-accession to power. 

Vital symptoms and signs

Extensive research has established that the fundamental drivers of health outcomes are social determinants. Unsurprisingly, the Taliban’s draconian restrictions that pervert the noble Islamic faith have dealt a crippling blow.

Women have been almost erased from public spaces (except when they are flogged), with restrictions on their movement, education, and employment. Women’s access to health care has shrunk, and very young girls are being forced into marriages to settle debts or relieve poverty.

Let us begin with basic health battlefield statistics. Afghans die young, with a life expectancy of 66.3 years, and under-five child mortality exceeding 50 deaths per 1,000 births – some 40% above the global average. 

Mothers suffer one of the world’s highest mortality ratios at 638 deaths per 100,000 livebirths. All these numbers were improving but have reversed under the Taliban.

Fourteen million Afghans – a third of the population – face crisis-level hunger and there is record-breaking malnutrition with around 4.9 million children and pregnant and breastfeeding women affected. This equates to a tenth of children acutely malnourished and 45% chronically stunted. 

Other conditions – communicable, non-communicable, physical and mental trauma – flourish. Suicide rates, especially among females, are mounting.  Six million coerced refugee returns from Pakistan and Iran, and climate disasters add to the strain.

Malnutrition amongst children and the wider public has reached record levels in Afghanistan.

When levers crumble

All this is familiar. But it is also well known that regimes that claim divine inspiration are not amenable to earthly leverage by traditional aid, trade, diplomatic and military tools, as I discovered in my role as a past special adviser to the United Nations Assistance Mission in Afghanistan (UNAMA). 

Meanwhile, the Taliban are amenable to receiving assistance but on their own terms. That poses a dilemma for those who wish to relieve the suffering of Afghans without supporting their autocratic and misogynistic rulers. 

So the real question in a country that has always been aid-dependent becomes: how to help, also knowing that Taliban regulations complicate aid delivery and utilisation, especially as it is not possible to employ women to reach vulnerable families.

This creates a difficult picture for foreign policymakers, who have many complex problems elsewhere to deal with. With the second coming of the Taliban in 2021, they found it much easier to walk away, whatever the morality of leaving Afghanistan to its own devices in light of the historic responsibilities of external powers in creating the turmoil. 

The walkout, in numbers

The principal consequence of the walkout has been felt in the aid sector. UN-coordinated funding dropped 69% from $3.27 billion in 2022 to $1.01 billion last year. 

Afghanistan’s 2026 humanitarian appeal seeks $1.71 billion. With three-quarters of the year gone, it has received just 30% or $513 million (30 August). 

The health cluster has around $73 million, or 38% of what it wants; nutrition has $51 million (17%), and water, sanitation and hygiene received $19.5 million (12%).

As a consequence, some 445 health facilities closed or suspended operations during 2025 and another 295 in the first half of this year. This includes 203 mobile health and nutrition teams. This means that at least four million people had lifesaving services switched off, including Khatera’s village.

Prevention and public health services also dwindle. The epicentre of wild poliovirus has shifted to Afghanistan with 19 cases this year compared to Pakistan’s three, as house-to-house vaccination stopped in October 2024 and women vaccinators became rare.

Meanwhile, and with no trace of irony, Afghanistan’s de facto Ministry of Public Health has just launched a surreal document with the vision of health as “a fundamental right” and a “goal of care for all Afghans”. 

This is its National Health Strategy 2026-2030 prepared with WHO support. One of its “seven pillars” concerns human resource development. It is not clear how this will be squared with the Taliban bar on women studying medicine, midwifery, nursing, and allied sciences, closing the pipeline for producing the clinicians Afghan women need. 

Does cutting aid kill?

The political economy of aid requires deeper scrutiny. Do aid cuts lead to deaths? The US Secretary of State has asserted that it does not, as the US drastically cut foreign assistance. It is difficult to attribute specific mortality to general loss of aid, especially in Africa where American aid cuts have, in part, been made up by host budgets and other donors.

But the causal association is stronger in Afghanistan, where neither the Taliban authorities nor other donors have stepped in to replace sharply dwindled US assistance, which had peaked above 40% of the country’s humanitarian spend. 

The US gave $728.6 million in 2024, $243.2 million in 2025, and nothing so far in 2026. An interesting study provides frontline evidence of impacts, such as neonatal deaths in Kunar and Farah rising 156% and 167% respectively between 2024 and 2025.

Two sides of the humanitarian red line

But there is a paradoxical aid economy at work. Even with pre-Taliban funding, most aid bypassed the government budget – except for some health basics. 

Since 2021, that has also gone, with UN agencies contracting providers that pay nurses and midwives directly into their personal bank accounts. So cutting such assistance does not defund the Taliban administration but individual health workers.

Thus, the ‘no Taliban support’ dogma costs nothing to their officials standing on one side of the humanitarian red line and everything to the beneficiaries on the other side. No Taliban enforcer misses a meal when yet another aid-funded nutrition site shuts.

Meanwhile, some $4.2 billion of Afghan central bank money sits in a Fund for the Afghan People at a Geneva non-profit foundation that has not disbursed a single dollar since its creation in 2022.  There is a further $3.5 billion frozen in the US and snarled up in post 9/11 litigation. 

And so, Afghanistan’s own money sits idle in Western banks while an ideological contest fires off competing virtue signals over the emaciated and expired bodies of its most vulnerable citizens who were never consulted on any of it.

The wider aid chill

In parallel, aid implementers relying on Western governments remain wary of counter-terrorism law. On paper, there are humanitarian carve-outs including American general licences. But, amidst the friable present mood, who is so rash as to trust a piece of paper?

Apart from cumbersome procedures and added administrative costs around getting waivers, imagine what happens if an agency makes a small payment for rendered services to a doctor who happens to have a Taliban relative, or a local Taliban official demands a small tax on the cash transfer. The agency could inadvertently face the nightmare of legal penalties and criminal prosecution.

Meanwhile, the general donor trend of conditioning humanitarian aid accelerates. Thus, $2 billion US global humanitarian funding via OCHA specifically excludes Afghanistan. Perhaps partly because the Taliban will not agree to a US return to control the strategic Bagram airbase

Although the European Commission – now Afghanistan’s biggest donor – has maintained funding levels (around €162 million this year), it also invited the Taliban to Brussels to discuss repatriating failed Afghan asylum seekers. 

With some 500,000 Afghans applying for asylum since the Taliban came, and the increased political toxicity associated with the migration issue, there is a trend towards attaching conditions to European aid.

As Western-espoused humanitarian values sink under their own hypocrisy and the world order splits into ‘the West’ and ‘the Rest’, Afghanistan is finding new friends.

China is courting the Taliban with infrastructure investments in return for accessing Afghanistan’s massive mineral resources. Russia is giving some aid alongside military co-operation to bring Afghanistan into its sphere of influence. Central Asian and Gulf nations, as well as India and Iran, get closer to the Taliban through aid, trade, and diplomacy. This further entrenches the Taliban regime and brings little succour for people.

Creative ways to bypass Taliban

Afghan women and children are paying the highest price for plunging aid.

That makes it even more vital to maximise the good effects of available limited humanitarian funding. This translates into aid givers finding creative ways to bypass the Taliban without getting thrown out themselves. 

That high-wire act to stay in the game to do good is the real story from the past five years. It is a tale of the extraordinary resilience of the Afghan people and their own traditional community and social institutions. And a tale of redemption for the very same aid agencies – UN and NGO – that are so heavily criticised for their shortcomings in other corners of the world.

Here are a dozen key strategies learnt from their trial, error and courageous risk-taking that are saving lives here and there in Afghanistan. These deserve scaling up while implementers stay under the Taliban radar as much as possible.

The first is about realising that aid delivery in Afghanistan is a retail affair, not a wholesale business. It requires negotiating for access locally and quietly, knowing that fierce-sounding national decrees are enforced unevenly. Province-by-province technical exemptions, brokered by Afghan staff and elders rather than announced from Geneva or Kabul, have, for example, kept some female vaccinators and midwives working.

Second, more of the dwindling numbers of Afghan professionals could be pressed into service to sustain healthcare frontlines. It means expanding direct-to-worker electronic payments, which would also inject cash into local economies without going through Taliban coffers. Electronic transactions are also easily tracked and audited to encourage small agencies fearing Western anti-terror legislation to expand their services.

Third, pay the mahram, the authorised male required under Taliban restrictions to accompany a female patient or the female health worker going to work. If this offends our Western sensibilities, think of the mahram as staff akin to the clinic watchman or ambulance driver. We are already compromising on mahram in practice while refusing to fund them in principle, which buys us the moral posture and the dead mother alike.

Some communities show incredible creativity with the mahram requirement. For example, groups of women going together to a health centre have negotiated to be escorted by a village elder as their ‘collective mahram’ – thereby allowing their wage-earning husbands, brothers, and sons not to take time off work.

Fourth, where patients cannot travel to clinics, bring them to her. Mobile health and nutrition units are well-known worldwide. Restoring and expanding Afghanistan’s mobile teams whose funding was indiscriminately cut would be a cost-effective boost for healthcare provision.

A mother and her child in a WHO-supported maternal care facility in Bajnab, Afghanistan.

Fifth, co-locate necessary institutional facilities such as operating rooms, laboratory and diagnostic capacities with existing national, provincial, and district hospitals, and re-equip and re-supply them. This makes it politically difficult for the Taliban to close them. Installing or repairing an ultrasound machine and refurbishing hospital electricity and water saves lives and does not mean condoning the Taliban administration.

Sixth, direct-to-clinic logistics that move vital medicines, therapeutic foods and other supplies from cargo planes to pharmacies under trusted supervision help to minimise diversion and reduce manipulated distribution.

Seventh, investing in autonomous, solar-powered clinic microgrids, including battery storage, has many benefits, not just for preventing the ruin of temperature-sensitive vaccines but also to allow anaesthesia and surgery for common trauma, obstetric, and other emergencies.

Eighth, revive grassroots public health surveillance for marker diseases, hunger and malnutrition, and vital statistics collection around births and deaths. That means paying local community enumerators as done in past smallpox and polio campaigns. It is when operational circumstances are most complex, that programmes cannot afford to go blind from lacking local trend data.

Ninth, take more measured risks. As international humanitarianism retreats while the “duty of care” movement gathers momentum, risk-aversion and institutional self-protection also grow. Understandable, of course, but is this not getting over the top? This is one of the most expressed frustrations by motivated and seasoned aid workers. Risk assessment systems – including utilising AI – have advanced but many agencies are stuck in centralised modes that mistrust well-informed local judgements.

That triggers another thought. With the growing shortage of female Afghan health professionals, could more foreign females volunteer to fill the gap? That raises the associated challenge of their accompanying mahram. There are pragmatic solutions here, including negotiating ad hoc exemptions or facilitating couples to serve together.

Tenth, keep the health and training pipeline rumbling along. Afghanistan’s education sector provides remarkable inspiration through clandestine home and digital schooling initiatives for girls. Can these approaches be applied in the health sector, both for refreshing basic health worker knowledge and for general public education around essential skills such as first aid, nutrition, and preventing and treating common conditions, including psychosocial support and suicide risk handling? 

Further, by investing in enhanced digital connectivity in selected (especially secondary) hospitals via low-cost technologies like Starlink that are available worldwide, expert Afghan medical diaspora with relevant linguistic skills could provide online consultations.

Eleventh, sustaining a health delivery system that works for people is a crucial concern as there is no possibility of political change in the foreseeable future. Meanwhile, high-profile international aid brands and large corporate logos draw intense, negative Taliban scrutiny. 

They could, instead, sponsor low-profile hyper-local community networks via pre-existing local volunteer bodies and underground civic networks to distribute medical micro-assistance, including medicines, hygiene kits, consultation referrals, and even skills training.

Twelfth, and most crucially, health aid givers should agree on common operating rules pragmatically applied in local circumstances. That means less policy rhetoric on confrontational red lines and more about working solutions that focus on patients. 

Facility-by-facility, the Taliban morality inspectors are conceding that medical spaces be demilitarised. Also female and male colleagues may work alongside each other during lifesaving procedures. Such bargains can be built upon.

Consistency and patience are missing

The Taliban rank-and-file know that their loved ones also need healthcare, often under desperate circumstances. Their rigid mindsets are curiously mirrored in their respect for others who also stubbornly hold onto their own principles. Hence, a package of negotiated measures that bring predictable cooperation over health is quite feasible, as shown by pioneering agencies such as Médecins Sans Frontières.   

In short, much more can be done to safeguard the health of Afghans despite numerous obstacles. There is nothing novel in the proposed approaches that have already shown good results in Afghanistan and other complex resource-poor contexts.

So what is missing? Beyond insufficient resources, it is a sense of coherent mission that believes in the feasibility of improving the health chances of Afghans. This will not come from the current defeatist attitudes among humanitarian, global health, and multilateral aid communities with low expectations and marked risk aversion. Neither will it come from composing national health strategies that are little more than fantasies. 

We need pragmatic but consistent labouring from the bottom-up organised around whatever Afghans find feasible. Above all is the requirement for patience that the international community is not known for.

 

Mukesh Kapila is professor emeritus of global health and humanitarian affairs at the University of Manchester, and a board member of Health Policy Watch. Vital Signs in Global Health is a regular column, and the opinions expressed are solely those of the author. 

Image Credits: Charlotte Cans/ UNOCHA, Karimi/ UNICEF Afghanistan, WHO EMRO, WHO.

Sex worker advocate Precious Mafanga describes lenacapavir as very easy to take for her sector.

The antiretroviral medicine lenacapavir, delivered via injection every six months, is almost completely effective in preventing HIV. But it is expensive at present, and millions will need to be initiated on it every year to make a dent on HIV transmission in South Africa.

CAPE TOWN – South Africa has the biggest population of people living with HIV in the world – over eight million people, around 18% of those aged 15 to 49. So its Health Ministry and researchers are laser-focused on HIV prevention tools, particularly how to optimise pre-exposure prophylaxis (PrEP), which involves using antiretroviral medication to prevent HIV.

The newest PrEP offering is lenacapavir, Gilead’s “miracle” twice-yearly injection that has prevented almost 100% of HIV transmission in clinical trials, some of which took place in South Africa.

The country started to roll out lenacapavir in June, and it is now available at 360 health facilities to anyone who feels at risk of HIV.

South Africa’s President Cyril Ramaphosa described the introduction of lenacapavir as “a major turning point in South Africa’s national story. It is the triumph of science over despair and the power of innovation to save lives”.

But fewer than 47,000 people have been initiated so far – mainly because the health department cannot afford a huge rollout.

Yet health economists advising the government have worked out that the country needs to get at least 1.7 million people on lenacapavir every year for the next five years if it wants to break the transmission of HIV.

Drug price and procurement

Hasina Subedar, senior technical advisor to the South Africa Department of Health.

The Global Fund, which has an agreement with Gilead, is procuring the drug for South Africa, and has asked the health department to ring-fence $29.2 million of its three-year Global Fund grant for lenacapavir.

“The Global Fund asked us to budget for $60 per person per annum, and it is topping this up, but the price they are paying [to Gilead] is confidential,” says Hasina Subedar, senior technical advisor at the South African Department of Health.

This budget translates into doses for around 420,000 people. While the United States government is assisting other countries to buy lenacapavir, it decided not to support South Africa over political disagreements. However, the Children’s Investment Fund Foundation (CIFF) has stepped in to assist the country.

“We will really only be able to have roll-out at scale when we have the generics,” says Subedar, noting that lenacapavir has been included on the country’s essential medicines list, subject to the availability of generics at $40 per annual dose.

In October 2024, Gilead announced that it has signed non-exclusive, royalty-free voluntary licensing agreements with six pharmaceutical manufacturers to make and sell generic lenacapavir for 120 “high-incidence, resource-limited countries”. It has prioritised 18 of these countries, including South Africa.

The six are Dr Reddy’s Laboratories, Emcure, Eva Pharma, Ferozsons Laboratories Limited, Hetero and Mylan – none South African.

So far, only Hetero has submitted its dossier for regulatory approval to the South African Health Products Regulatory Authority (SAHPRA). Generics are expected by mid-2027, but it is unclear yet when they will reach South Africa.

Lumps and bumps: administering lenacapavir

South African health facilities have offered oral PrEP since 2016, although the small supplies initially available were first directed to groups most at risk: sex workers, then men who have sex with men and then teenage girls and young women.

Since its introduction, some 2.3 million people have started oral PrEP, but have stopped taking the pills. Supply has been affected by the 2025 US budget cuts. But some people also get tired of daily pill-taking.

Others, particularly vulnerable young women, are reluctant for their partners to know that they are taking precautions against potential HIV infection. 

This makes the six-monthly injectable option so attractive. But it’s not a simple process, as Subedar explains.

Lenacapavir initiation happens over two days. On day one, people get two 1.5ml injections in separate areas, administered subcutaneously (in the fatty layer of skin). This is usually in the person’s abdomen or buttocks. At the same time, they get two 300mg pills.

People are sent home with two 300 mg pills, which they need to take the following day.  By day three, they are protected against HIV for the next 26 weeks until their next injections. They have a two-week grace period either side of their 26-week date to get their next injections. No pills are needed on subsequent visits unless they miss the two-week window.

Patients’ experiences: ‘Next time, the buttocks’

Trans activist Dimpho Tsotetsi says oral PrEP made me nauseous.

Dimpho Tsotetsi, who has used oral PrEP since 2017, switched to lenacapavir in a Soweto clinic on 4 July.

“I used to work in a [USAID] donor-funded clinic, so I knew it was coming,” said Tsotetsi, an extroverted 32-year-old trans woman who describes herself as a health advocate for her community.

“I had nausea every day with oral PrEP,” she added, and despite about two weeks of discomfort after her injections, Tsotetsi describes the experience as “pleasant”. 

“I got two shots on my stomach, one on the left, one on the right. Until today I still have the bumps. I can feel them,” said Tsotetsi, who adds that this has made wearing clothes with tight waistbands harder as they rub against the injection bumps.

 “Hence I’m wearing something flowy”, she laughs.

Precious Mafanga, a sex worker and sex worker advocate, describes lenacapavir as “very helpful and easy to take” – unlike oral PrEP “which makes you hungry”.

She and many others working in organisations serving “key populations” – those most at risk of HIV – have had a rough time since the US stopped funding these groups after Donald Trump came to power in January 2025.

Mafanga describes chaos in the sex worker sector, with job losses for peer educators, sex workers defaulting on antiretroviral medication and a lack of support for people who inject drugs as specialised clinics and mobile outreach came to a screeching halt.

In the past few months, a new organisation, Tholwana e Molemo, has stepped up to assist sex workers. While resources are much more limited, the organisation’s nurses have been able to work with government clinics to enable sex workers to get fast access to lenacapavir.

Lindiwe Mqatazana, who is pregnant, opted for lenacapavir to protect her baby.

Meanwhile, Siviwe Gaika, a 24-year-old law student and church-goer who uses PrEP to protect herself, said she tried to get lenacapavir three times before her local clinic, a designated site, was ready to administer it.

She also describes bumps on her abdomen at the injection sites: “I think next time I will get it on the buttocks.”

It was the buttocks for Lindiwe Mqatazana, who had a positive pregnancy test and lenacapavir all in the same day.

“It was a bit scary, but the nurses explained that this is the best way to protect my baby and that it won’t hurt the baby,” said Mqatazana.

Million-person rollout

Dr Lise Jamieson from the Health Economics and Epidemiology Research Office (HE2RO) at Wits University is one of the health economists advising the health department.

Using Thembisa,  a mathematical model of the South African HIV epidemic, researchers have made various forecasts, said Jamieson. Their key message is that lenacapavir will be far more effective than oral PrEP – if it is rolled out at scale.

The impact of lenacapavir in comparison to oral PrEP (TDF/ FTC)

After modelling various scenarios, they calculate that lenacapvir can reduce HIV by 19-31% over 20 years in comparison to 4% by oral PrEP. It will also end AIDS seven to 10 years earlier than oral PrEP.

But this impact requires serious volumes: between 1.7 million and 2.3 million people need to start lenacapavir every year for at least the next five years.

The rollout needs to be more targeted at those who need it most, with the most optimal breakdown to be 45% for adolescent girls and young women (AGYW); 30% for men who have sex with men (MSM); 15% for female sex workers; and 10% for pregnant and breastfeeding women.

The health department’s targets are weighted more heavily towards teenage girls, young women, and pregnant and breastfeeding women. However, currently it is hard to tell which groups most of the 47,000+ people who have opted for lenacapavir come from, as over 70% describe themselves as the “general population”.

Targeting certain key populations – female sex workers (FSW), men who have sex with men (MSM), and adolescent girls and young women (AGYW) – will have more impact than an over-emphasis on pregnant and breastfeeding women (PBFW), according to experts.

Meanwhile, the financial investment is substantial, with up to $106 million needed for five years – but, says Jamieson, this is still four times more cost-effective than oral PrEP.

More choices

“The excitement about lenacapavir is huge, but what is the follow-up going to be like?” asks Dr Pippa McDonald, from the Desmond Tutu Health Foundation. The foundation was one of the partners that ran the clinical trial of lenacapavir, and is currently monitoring people’s responses and uptake to the medication.

So far, over 80% of people surveyed want the six-monthly injections rather than oral PrEP, said MacDonald.

“Choice is really important,” says MacDonald, who believes that offering different PrEP options and points of delivery are important ingredients for success.

A monthly PrEP pill, alimatravir, is currently undergoing clinical trials – and may prove even more popular than the six-monthly injections.

At the International AIDS Society (IAS) conference in Brazil in July, the company developing the pill, Merck/ MSD, announced that it has already granted voluntary licenses to seven generic companies – three in sub-Saharan Africa and four in India – to produce the medicine for 129 low- and middle-income countries. This is even before the medicine has been proven effective.

There are many possibilities in the mix, including the government distributing PrEP in partnership with private pharmacies and people self-injecting follow-up lenacapavir doses.

But there are still many unknowns too, particularly how fast generic lenacapavir can be produced, whether there will be enough money for the scale-up that is needed, and how many people will come back after six months.

Interviews for this article are from a media workshop on South Africa’s lenacapavir rollout organised by Bhekisisa.

Dr Piyush Bharadwaj, CSTEP, presenting research on the air quality and climate co-benefits possible in India at the India Clean Air Summit.

BENGALURU – India’s flagship air pollution action plan, the National Clean Air Programme (NCAP), has mostly failed to deliver, according to research presented at the eighth India Clean Air Summit. 

Officials, scientists, and other experts highlighted the 2019 program’s severe shortcomings and red-flagged critical gaps. An “NCAP 2.0′ has been widely expected, but the central government has yet to announce a launch timeline.

Data shared by the summit organiser, the Center for Study of Science, Technology and Policy (CSTEP), showed that fewer than 7% of the 131 targeted cities met NCAP’s goal to reduce pollution by 40% by 2025-26, and 35% of cities showed an increase in coarse particulate matter (PM10). This failure comes despite the government releasing over INR 16,423 crore (approximately $1.5 billion) to support the program.

Speakers at the conference emphasized that future iterations of the programme must bridge air pollution control measures with climate action policies. Crucially, at least two government experts warned of emerging, interconnected feedback loops between climate change and air quality.

Structural flaws in programme

According to CSTEP, NCAP’s limited impact stems from several core design flaws. These include that it targets cities; focuses on PM 10 and dust mitigation measures not the finer, deadlier PM2.5 particulate matter pollutant; has no systemic assessment of interventions; and it covers short-term measures rather than long-term planning considering growth. There is also limited technical understanding of urban local bodies (ULBs). 

About 95% of India’s PM2.5 pollution, a universally tracked pollutant, is emitted from cities and rural areas that are excluded from NCAP’s focus, which tracks 131 cities. Seventy percent of PM2.5 is from “non-urban areas” according to PAVITRA, an air quality management tool developed by IIT Bombay, CSTEP and two American universities. 

Data shows how much of India’s air pollution sources lie outside cities and outside the National Clean Air Programme’s focus centres. Source: Air Pollution Management And Intervention Tool For India (PAVITRA), by IIT Bombay, CSTEP, University of Washington, Berkeley University of California.

Another limitation is the lack of funding for places where pollution is rising, such as the coastal state of Kerala.

“What I really want to request is that when NCAP 2.0 is happening, there should be some funds available to the cities which are not non-attainment, but are trying to prevent becoming a non-attainment city,” says Ratish Menon, a senior official of Kerala’s Pollution Control Board. 

Non-attainment means cities that have consistently failed to attain air quality that meets the national ambient air quality standard of 40 micrograms/cubic metre of PM2.5. 

Indo-Gangetic plain: India’s pollution hotspot

That plain stretches about 2,000 kilometres across northern India, south of the Himalayan foothills and east to Bangladesh.

However, the most severe challenge remains concentrated in northern plains of India, described as an “emission hotspot” by SD Attri, a senior official and scientist of the Commission for Air Quality Management (CAQM). The CAQM is in-charge of reducing pollution in and around Delhi, which is situated in the plains. 

“The Indo-Gangetic Plain (IGP) covers only 15% of India’s land but accommodates around 37% of its population and emits 35% of India’s total emissions, making it an emission hotspot,” Attri explained, which is why Delhi and other places here often make it to the list of the top, most polluted places in the world. 

Residents across the northern plains are exposed to persistently high pollution levels year-round. On an annual basis, average concentrations of PM2.5 or smaller particulate matter reach 84 µg/m³ (micrograms/cubic metre), which is more than twice the permissible standard of 40 micrograms under India’s National Ambient Air Quality Standard and almost 17 times the WHO’s safety guideline of 5 µg/m³ . 

Target mitigation: Black carbon in UP and Bihar

A sharper focus on just two states, Uttar Pradesh and Bihar, and one pollutant, black carbon or soot, has been recommended by a CSTEP report launched at the summit. 

The largest source of black carbon is from homes burning biomass and other dirty fuels for cooking and heating. And more than 60% of this pollution is from the IGP states. 

Uttar Pradesh and Bihar is where domestic emissions have the greatest regional spillover. These two states dominate India’s northern plains, with a combined area about the same as Finland but with a combined population larger than the US. 

Reducing black carbon emissions can save lives, and the largest benefits are to be achieved through a multisectoral airshed approach. Reducing black carbon emissions from all major sources in the IGP results in a 37% reduction in black carbon concentration and prevents 2,290 PM2.5-attributable premature deaths. 

This number is conservative, as the authors explain there is limited research on the health effects of black carbon, unlike that of PM2.5, which is linked to about a million deaths in the country. 

“The mortality burden estimated in this study is conservative because the exposure–response function used is derived for ambient PM 2.5 mass concentration rather than for individual PM 2.5 components (Black carbon, organic carbon, sulphates, nitrates, etc).

“Consequently, the potential toxicity of black carbon is not explicitly captured in the mortality estimation,” Piyush Bharadwaj, head of the air quality observations and modelling group at CSTEP, told Health Policy Watch.

Climate change – air pollution link

The CSTEP report also highlights significant co-benefits between clean air initiatives and carbon mitigation.

In a best-case scenario, aggressive black carbon reduction in northern India would yield climate co-benefits equivalent to 639.3 MT CO2, roughly similar to Germany or South Korea’s annual emissions.

Dr Ratish Menon, senior official, Kerala State Pollution Control Board, India

There were other warnings about the link between global warming and air pollution. Menon attributed part of the rise in Kerala’s air pollution levels to pollution from neighbouring states, but also to global warming. 

Last winter’s peak in “all (air quality monitoring) stations” was more because there was lesser wind transport between the land and ocean, he says, “because the ocean temperatures are increasing and that exchange is getting affected. That causes a regional buildup.”

A separate climate link was flagged by a senior scientist at IIT Kanpur, SN Tripathi, whose team has overseen the deployment of almost 1,400 low-cost sensors in Uttar Pradesh and Bihar. 

Based on this data, Tripathi said they have been able to create an index where “we have combined temperature and relative humidity to provide some kind of a universal climate index, and we are basically trying to give that how it looks during summer times when the temperatures are very high and the overall comfort level for human beings becomes very unmanageable.” 

They are seeing that a good part of these two states have a “very high amount of this compound index.” When asked by Health Policy Watch, how this ‘universal climate index’ is to be used, Tripathi said it was work in progress and premature to comment.

Call to change air quality action plans

India’s peak pollution season begins in October and ahead of that, Attri, the most senior official from the government of India at the summit, listed several measures taken to reduce air pollution.

The latest include increasing the number of top grade air quality monitoring stations from about 90 currently to 157 in the next month as well a “new GRAP” system which he says will be open for the public’s comments and suggestions; GRAP is the Delhi region’s Graded Response Action Plan, a series of tighter curbs – on transport, construction, diesel generators, cooking fuels and even schools – as pollution levels rise 

However, the larger messaging from ICAS 2026 is that urgent changes in air quality management are required. Pointing to a series of policy actions since the Air (Prevention and Control of Pollution) Act was cleared by Parliament 45 years ago, and the INR 16,423 crore in funding released by the government, Abinaya Sekar of Health Effects Institute underscored the need to assess the effectiveness of air pollution interventions, offering a framework on how to do this.

CSTEP researchers urged the government to integrate air quality targets into both NCAP 2.0 and India’s international commitments under the UN Nationally Determined Contributions (NDCs), that is, self-identified pledges for climate action by every country. 

Aligning these policies would allow air quality improvement to be recognised as a critical element of near-term climate mitigation, particularly by targeting short-lived climate pollutants like black carbon.

In eight years of the India Clean Air Summit and similar gatherings, the one constant has been the demand for better implementation. 

The other constant has been Delhi’s annual average PM2.5 pollution level stubbornly hovering around 100 micrograms, in the last eight years.

Image Credits: Source: Press Information Bureau, Indian Government.

Meta agreed to limit social media notifications at night for teenagers.
Meta agreed to silence notifications for teens from midnight to 6:00 AM, but this excludes direct messaging and can be disabled by parents.

Following a landmark agreement in the United States on Wednesday, social media giant Meta agreed to pay up to $18 billion to US states. This historic settlement obliges the company to make Instagram and Facebook safer for children.

Scientific research – including a landmark report by an expert panel commissioned by the European Commission – shows that excessive social media use damages early childhood brain development and fuels mental health crises among young people. Meta emphasises that the settlement is not proof of harmful health effects caused by its platforms.

However, the unprecedented sum is likely to increase global pressure on platform operators to take action. The company said it had agreed to distribute the payments in annual instalments over a 10-year period to fund youth online safety initiatives across the participating states.

Meta limits social media access for youth

The agreement stipulates that Meta must limit daily usage time to two hours, disable extreme beauty filters, pause nighttime notifications and hide ‘like’ counts on posts by teenagers.

In addition, the company will implement an age verification system under which no more than 3% of 13- to 15-year-olds and 10% cent of older teenagers may be incorrectly classified as adults.

“The framework we’ve negotiated will empower parents to easily manage how their children access our platforms,” said CJ Mahoney, chief legal officer at Meta in a statement on Wednesday.

Meta is required to phase in these modifications, with a strict compliance deadline set for six months after the court has now approved the settlement. To prevent an exodus of young users, Meta is urging its competitors, YouTube and TikTok, to adopt these standards.

Doubts about effectiveness of settlement

However, experts question whether the agreed time limits will effectively curb deep-rooted addiction risks. Parents can easily disable these daily usage caps, and the overnight notification pause does not cover direct messaging.

Biometric facial scans for age verification remain controversial because processing sensitive video data violates data protection principles. Furthermore, teenagers easily bypass basic digital blocks using virtual private networks (VPNs), while privacy-friendly age verification methods remain unavailable on a large scale.

A signal to regulators worldwide

Nevertheless, the US settlement establishes a benchmark for youth social media bans passed in Australia and proposed in New Zealand.

The European Commission plans to introduce a draft regulation this autumn to enforce a harmonised European age limit and strict safety-by-design standards. This proposed framework aims to end the current patchwork of legislation across Europe, as national restrictions often clash with the strict rules of the EU’s Digital Services Act (DSA).

Related Story:

Warning labels, Time restrictions? Experts Mull How to Curb Social Media Harms

Editorial note: The piece has been updated on 28 August to reflect that the court has now approved the settlement.

Image Credits: cottonbro studio via Pexels.